You can uninstall Backbone Work Sync from your instance by going to the manage app section. When you uninstall Backbone from your instance, the following will happen:
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The sync panel on the issues synced will be removed
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Updates between the previously synced issues will no longer be synced
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The issues synced will not be deleted (Backbone never deletes any issues)
Reinstalling Backbone
When reinstalling the app, all your previously created Backbone synchronization are still there. You can start synchronizing where you left off.